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Pediatric Clinical Trials

Department of Hematology/Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

Correspondence: Charles B. Pratt, M.D., St. Jude Children’s Research Hospital, Department of Hematology/Oncology, 332 North Lauderdale, Memphis, TN 38105, USA. Telephone: 901-495-3442; Fax: 901-521-9005.

Clinical trials specifically tailored to the unique tumors and leukemias of children have resulted in increased survival rates approaching or exceeding 70% for most diseases. These studies have been carried out by investigators at large, independent institutions or through the auspices of the Children’s Cancer Group or Pediatric Oncology Group. The National Cancer Institute has also supported pediatric disease—focused efforts for rhabdomyosarcoma, Wilms tumor, Ewing’s sarcoma, osteosarcomas and other diseases. The present-day training of pediatric hematology/oncology fellows assures continuing contributions to the biology of childhood malignant lesions through applications of translational research.

Key Words. Childhood tumors • Leukemia • Chemotherapy • Surgery • Radiation therapy

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