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Modulating the Radiation Response

Joint Center for Radiation Therapy, Harvard Medical School, Boston, Massachusetts, USA

Correspondence: C. Norman Coleman, M.D., Joint Center for Radiation Therapy, Harvard Medical School, 50 Binney Street, Boston, MA 02115, USA. Telephone: 617-432-1889; Fax: 617-432-3779.

This review describes some current and future approaches designed to modulate the response of tumors and normal tissues to cell killing by ionizing radiation. The emerging knowledge of tumor, cellular and molecular biology is providing a better understanding of the clinical results with the hypoxic cell sensitizers and novel approaches to radiation sensitization and protection.

Key Words. Radiation therapy • Radiation biology • Radiation oncology • Radiation modifiers • Radiation sensitizers • Sensitizers