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ADVANCES IN CANCER TREATMENT: THE CHABNER SYMPOSIUM |
Vanderbilt University School of Medicine, Nashville VA Medical Center, Nashville, Tennessee, USA
Correspondence: Kenneth R. Hande, M.D., Vanderbilt University School of Medicine, Medical Oncology, 1956 The Vanderbilt Clinic, Nashville, TN 37232, USA. Telephone: 615-322-4967; Fax: 615-343-7602.
Etoposide is a drug whose antineoplastic activity is dependent on the schedule of drug administration. This article reviews the rationale for a prolonged schedule of etoposide administration and the therapeutic results of use of such a schedule in the treatment of cancer. The pharmacology of etoposide is also reviewed, with particular attention paid to the pharmacokinetics of oral etoposide and etoposide plasma concentrations associated with cytotoxicity.
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