This Article Full Text Full Text (PDF) eLetters: Submit a response to this article Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services E-mail this article link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Metzger, M. L. Articles by Dome, J. S. Search for Related Content PubMed PubMed Citation Articles by Metzger, M. L. Articles by Dome, J. S.

Current Therapy for Wilms’ Tumor

Department of Hematology-Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

Key Words. Pediatric cancer • Wilms’ tumor • Nephroblastoma • Therapy • SIOP • NWTS

Correspondence: Jeffrey S. Dome, M.D., Department of Hematology-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105-2794, USA. Telephone: 901-495-2533; Fax: 901-495-3966; e-mail: jeff.dome{at}stjude.org

Wilms’ tumor was the first solid malignancy in which the value of adjuvant chemotherapy was established. Multimodality treatment has resulted in a significant improvement in outcome from approximately 30% in the 1930s to more than 85% in the modern era. Although the National Wilms’ Tumor Study Group and the International Society of Pediatric Oncology differ philosophically regarding the merits of preoperative chemotherapy, outcomes of patients treated with either up-front nephrectomy or preoperative chemotherapy have been excellent. The goal of current clinical trials is to reduce therapy for children with low-risk tumors, thereby avoiding acute and long-term toxicities. At the same time, current clinical trials seek to augment therapy for patients with high-risk Wilms’ tumor, including those with bilateral, anaplastic, and recurrent favorable histology tumors.

This article has been cited by other articles:

				A. A. Morrison, R. L. Viney, M. A. Saleem, and M. R. Ladomery New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes Am J Physiol Renal Physiol, July 1, 2008; 295(1): F12 - F17. [Abstract] [Full Text] [PDF]

				P. R. Bhosale, M. Patnana, C. Viswanathan, and J. Szklaruk The Inguinal Canal: Anatomy and Imaging Features of Common and Uncommon Masses RadioGraphics, May 1, 2008; 28(3): 819 - 835. [Abstract] [Full Text] [PDF]