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The Oncologist, Vol. 10, No. 8, 613-622, September 2005; doi:10.1634/theoncologist.10-8-613
© 2005 AlphaMed Press

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Fertility-Sparing Options for Patients with Gynecologic Malignancies

Mario M. Leitao, Jra, Dennis S. Chib

a Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women’s Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA; b Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

Correspondence: Dennis S. Chi, M.D., Memorial Sloan-Kettering Cancer Center Gynecology Service, Department of Surgery, 1275 York Avenue, New York, New York 10021, USA. Telephone: 212-639-5016; Fax: 212-717-3214; e-mail: chid{at}mskcc.org

Gynecologic malignancies are most often diagnosed in postmenopausal women, but these malignancies also arise in premenopausal women, in whom issues of fertility can be a major concern. An increasing number of women are delaying childbearing. This has led to a significant increase in the number of women diagnosed with a gynecologic malignancy before desired completion of childbearing. Many of the standard treatments for these malignancies result in permanent sterility; however, there are now options for select young women who desire to preserve fertility. Patients should be told that data on fertility-sparing procedures are limited and that many of these options are of an experimental, nonstandard nature. The care of these patients is challenging and complex and requires a multidisciplinary approach, which should include gynecologic oncologists, reproductive endocrinologists, and perinatologists.

Key Words. Fertility-sparing • Ovarian cancer • Cervical cancer • Endometrial cancer • Radical vaginal trachelectomy • Ovarian transposition






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