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Lymphoma

Non-Hodgkin’s Lymphoma of Mucosa-Associated Lymphoid Tissue

^a St. Luke’s-Roosevelt Hospital Center, New York, USA; ^b Beth Israel Medical Center, New York, USA; ^c Continuum Cancer Centers of New York, New York, USA

Key Words. Mucosa-associated lymphoid tissue • Non-Hodgkin’s lymphoma • Helicobacter pylori

Correspondence: Michael L. Grossbard, M.D., Division of Hematology/Oncology, St. Luke’s-Roosevelt Hospital Center, Suite 11G, 1000 10th Avenue, New York, NY 10019, USA. Telephone: 212-523-5419; Fax: 212-523-2004; e-mail: mgrossbard{at}chpnet.org

The concept of mucosa-associated lymphoid tissue (MALT) lymphomas was introduced by Isaacson and Wright [ Cancer 1983; 52:1410–1416[CrossRef][Medline] ] in 1983. After more than 20 years of clinical research MALT lymphomas are now recognized as a distinct subtype of non-Hodgkin’s lymphoma (NHL) with unique pathogenic, histological, and clinical features. Although this subtype of NHL occurs frequently, optimal management remains elusive. This manuscript reviews features of the clinical presentation, diagnosis, pathology, molecular characteristics, and management of both gastric and non-gastric MALT lymphoma.

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