The Oncologist, Vol. 11, No. 6, 674-680, June 2006; doi:10.1634/theoncologist.11-6-674 © 2006 AlphaMed Press
Post-Transplant Lymphoproliferative DisordersDivision of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Key Words. PTLD • Early Lesion • Polymorphic PTLD • Monomorphic PTLD Correspondence: Ann S. LaCasce, M.D., Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. Telephone: 617-632-5959 Fax: 617-632-5890; e-mail: Ann_LaCasce{at}dcfi.harvard.edu
Post-transplant lymphoproliferative disorder is the most common malignancy, with the exception of skin cancer, after solid organ transplantation in adults. The incidence varies according to the transplanted organ and is often associated with Epstein-Barr virus. Prognosis is variable, due in part to the heterogeneity of the disease, which ranges from reactive plasmacytic hyperplasia to aggressive monoclonal disease.
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