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The Oncologist, Vol. 11, No. 9, 981-987, October 2006; doi:10.1634/theoncologist.11-9-981
© 2006 AlphaMed Press

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Special Section on Colorectal Cancer

Therapy for Metastatic Colorectal Cancer

Richard M. Goldberg

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Key Words. FOLFOX • FOLFIRI • Bevacizumab • N9741 • PTK 787 • Cetuximab

Correspondence: Richard M. Goldberg, M.D., CB # 7305, 3009 Old Clinic Building, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Telephone: 919-966-5720; Fax: 919-966-6735; e-mail: goldberg{at}med.unc.edu

Median overall survival of metastatic colorectal cancer patients treated with first- and second-line combination chemotherapy now extends to more than 20 months in some studies. Chemotherapy alone, particularly when oxaliplatin is included, may allow potentially curative resection of advanced disease. There is evidence that the addition of antibodies targeted against vascular endothelial growth factor or the epidermal growth factor receptor will further improve prospects for patients with advanced and metastatic disease. However, the optimum sequencing of chemo- and biological therapies remains to be established, as does the potential contribution of numerous agents in development.




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