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The Oncologist, Vol. 12, No. 3, 325-330, March 2007; doi:10.1634/theoncologist.12-3-325
© 2007 AlphaMed Press

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Lung Cancer

Second-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Lecia V. Sequist

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA

Key Words. Epidermal growth factor receptor • Non-small cell lung cancer • Tyrosine kinase

Correspondence: Correspondence: Lecia V. Sequist, M.D., M.P.H., Massachusetts General Hospital Cancer Center, 32 Fruit Street, Yawkey Suite 7B, Boston, Massachusetts 02114, USA. Telephone: 617-726-7812; Fax: 617-726-0453; e-mail: lvsequist{at}partners.org

Inhibiting epidermal growth factor receptor (EGFR) signaling has proven to be an effective strategy for treating non-small cell lung cancer (NSCLC) patients and the first generation of agents developed for this purpose, gefitinib and erlotinib, stimulated a unique escalation in both biologic and clinical research within the field. Second-generation EGFR-targeted agents that aim to further improve patient outcomes are now in preclinical and clinical trials. This review discusses four promising agents that are currently being studied in NSCLC: EKB-569, HKI-272, CI-1033, and ZD6474.

Disclosure of potential conflicts of interest is found at the end of this article.




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