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Lymphoma

Safe Administration of Iodine-131 Tositumomab After Repeated Infusion-Related Reactions to Rituximab

Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA

Key Words. Follicular lymphoma • Antibodies • Monoclonal • Radioimmunotherapy • Adverse effects

Correspondence: John Hayslip, M.D., 96 Jonathan Lucas Street, CSB 903, PO Box 250635, Charleston, South Carolina 29425, USA. Telephone: 843-792-4271; Fax: 843-792-0644; e-mail: hayslip{at}musc.edu

Infusion-related reactions during administration of monoclonal antibody therapy are often mild and unlikely to recur with subsequent treatment. If patients experience another severe reaction upon reattempting treatment, future treatments with the same agent are typically not pursued. It is unclear whether different monoclonal antibodies that bind the same tumor cell or antigen are likely to induce similar infusion reactions. Here, we report the case of a patient with repeated severe infusion reactions with rituximab who subsequently safely received treatment with iodine-131 tositumomab and discuss the relevant literature.

Disclosure of potential conflicts of interest is found at the end of this article.