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Breast Cancer

Some Aspects of the Endocrine Profile and Management of Hormone-Dependent Male Breast Cancer

Michigan State University, Department of Medicine, Division of Hematology/Oncology, East Lansing, Michigan, USA

Key Words. Hormone • Endocrine • Male breast cancer

Correspondence: Correspondence: Nikolay V. Dimitrov, M.D., Michigan State University, B413 Clinical Center, East Lansing, Michigan 48824, USA. Telephone: 517-353-3128; Fax: 517-432-9471; e-mail: dimitrov{at}msu.edu

The management of hormone-dependent male breast cancer is insufficiently understood by practicing oncologists. This article provides a review of the endocrine profile of male breast cancer, and outlines the differences between hormone-dependent female and male breast cancers. A concise review of the past, present, and possible future management of hormone-dependent male breast cancer is presented. For a better understanding of this disease, more information on the natural history and biological behaviors of patients with male breast cancer is needed. This could be accomplished by the development of a specific multi-institutional tumor registry and execution of prospective clinical trials.

Disclosure of potential conflicts of interest is found at the end of this article.