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The Oncologist, Vol. 12, No. 9, 1070-1083, September 2007; doi:10.1634/theoncologist.12-9-1070
© 2007 AlphaMed Press

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 Commentary: Oncologic Drugs in Patients with Organ Dysfunction: A Summary
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Clinical Pharmacology

Commentary: Oncologic Drugs in Patients with Organ Dysfunction: A Summary

Diana Superfin, Andrea A. Iannucci, Angela M. Davies

University of California Davis Cancer Center, Sacramento, California, USA

Key Words. Hepatic • Renal • Dysfunction • Chemotherapy • Cancer

Correspondence: Correspondence: Angela M. Davies, M.D., F.R.C.P.C., Hematology/Oncology, University of California Davis Cancer Center, 4501 X Street, Suite 3016, Sacramento, California 95817, USA. Telephone: 916-734-3771; Fax: 916-734-7946; e-mail: angela.davies{at}ucdmc.ucdavis.edu

Disclosure: A.M.D. has acted as a consultant for Bristol-Myers Squibb, Allos Therapeutics, CTI Therapeutics, Genentech, Millennium, and Lilly, and has received support from Genentech and Aventis.

There are few prospective data regarding the pharmacokinetics and clinical toxicity of commonly used chemotherapeutics in cancer patients with organ dysfunction. Although increasing numbers of studies are investigating newer chemotherapeutics in patients with liver or kidney dysfunction, most guidelines for dosing, especially for established agents, remain empiric. This review describes the available data (both prospective and case study) evaluating the impact of renal and hepatic dysfunction on toxicity and dosing of commonly used chemotherapeutics and provides a practical summary for their use in this setting.






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