Advertisement
help button home button The Oncologist
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
The Oncologist, Vol. 12, No. suppl_2, 7-13, October 2007; doi:10.1634/theoncologist.12-S2-7
© 2007 AlphaMed Press

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow eLetters: Submit a response to this article
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Segal, B. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Segal, B. H.

Role of Macrophages in Host Defense Against Aspergillosis and Strategies for Immune Augmentation

Brahm H. Segal

Roswell Park Cancer Institute, Buffalo, New York, USA

Key Words. Aspergillus • Colony-stimulating factor • Macrophage • Review

Correspondence: Brahm H. Segal, M.D., Division of Infectious Diseases, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, New York 14263, USA. Telephone: 716-845-5721; Fax: 716-845-5777; e-mail: brahm.segal{at}roswellpark.org

Disclosure: B.H.S. has acted as a consultant to Pfizer, Berlex, ViraCor, and Enzon, and has received speaking honoraria from Merck and Pfizer.

Invasive aspergillosis is a major cause of morbidity and mortality in highly immunocompromised patients with cancer. Alveolar macrophages ingest inhaled conidia (spores). Through pathogen recognition receptors that ligate fungal cell wall motifs, macrophages are able to coordinate the inflammatory response to Aspergillus species. Macrophages and dendritic cells play an important role in regulating the balance between the proinflammatory and anti-inflammatory cytokine responses that are required for recruitment and activation of neutrophils, and in augmenting or attenuating cellular immunity. Macrophages are therefore a target for immune augmentation strategies that include administration of cytokines, colony-stimulating factors, and pathogen recognition receptor ligands.




This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
E. Appel, A. Vallon-Eberhard, A. Rabinkov, O. Brenner, I. Shin, K. Sasson, Y. Shadkchan, N. Osherov, S. Jung, and D. Mirelman
Therapy of Murine Pulmonary Aspergillosis with Antibody-Alliinase Conjugates and Alliin
Antimicrob. Agents Chemother., February 1, 2010; 54(2): 898 - 906.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. T. Silva
When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
J. Leukoc. Biol., January 1, 2010; 87(1): 93 - 106.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. L. Werner, A. E. Metz, D. Horn, T. R. Schoeb, M. M. Hewitt, L. M. Schwiebert, I. Faro-Trindade, G. D. Brown, and C. Steele
Requisite Role for the Dectin-1 {beta}-Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus
J. Immunol., April 15, 2009; 182(8): 4938 - 4946.
[Abstract] [Full Text] [PDF]


HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
THE ONCOLOGIST STEM CELLS CME ALPHAMED PRESS JOURNALS


Copyright © 2007 by AlphaMed Press.
Advertisement