help button home button The Oncologist
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

First Published Online November 5, 2008
The Oncologist, Vol. 13, No. 11, 1193-1200, November 2008; doi:10.1634/theoncologist.2008-0188
© 2008 AlphaMed Press

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the course for this article:
Angiogenesis Inhibition in Non-GIST Soft Tissue Sarcomas
Right arrow All Versions of this Article:
theoncologist.2008-0188v1
13/11/1193    most recent
Right arrow eLetters: Submit a response to this article
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Google Scholar
Right arrow Articles by Sleijfer, S.
Right arrow Articles by Blay, J.-Y.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sleijfer, S.
Right arrow Articles by Blay, J.-Y.

Sarcomas

Angiogenesis Inhibition in Non-GIST Soft Tissue Sarcomas

Stefan Sleijfera, Winette T.A. van der Graafb, Jean-Yves Blayc

aErasmus University Medical Center, Rotterdam, The Netherlands; bRadboud University Nijmegen Medical Center, Nijmegen, The Netherlands; cCentre Léon Bérard, Lyon, France

Key Words. Soft tissue sarcoma • Angiogenesis • Vascular endothelial growth factor (VEGF)

Correspondence: Stefan Sleijfer, M.D., Ph.D., Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands. Telephone: 31-10-7041733; Fax: 31-10-7041003; e-mail: s.sleijfer{at}erasmusmc.nl

Received August 22, 2008; accepted for publication October 1, 2008; first published online in THE ONCOLOGIST Express on November 5, 2008.

Disclosure: Employment/leadership position: None; Intellectual property rights/inventor/patent holder: None; Consultant/advisory role: Jean-Yves Blay, GlaxoSmithKline; Honoraria: None; Research funding/contracted research: Stefan Sleijfer, noncommercial interest; Ownership interest: None; Expert testimony: None; Other: None.

The authors disclose that the article discusses unlabeled, investigational, or alternative use(s) of: pazopanib (GlaxoSmithKline), antiangiogenic; sorafenib (Bayer), antiangiogenic; sunitinib (Pfizer), antiangiogenic.

The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the authors, planners, independent peer reviewers, or staff managers.

Because angiogenesis is of crucial importance in the pathogenesis of cancer, blocking the function of proangiogenic factors has been shown to improve the outcomes of patients with several cancer types. Given the poor survival durations of patients with advanced soft-tissue sarcomas (STSs), which has remained stable at a median of 12 months over the last 20 year, there is an unmet need for novel agents active against these tumors. Like in other tumors, accumulating evidence points at an important role for angiogenic factors in STSs, rendering these factors attractive treatment targets. This review discusses the currently available evidence supporting a role for angiogenic factors in the pathogenesis of STSs and the first preliminary study results obtained with angiogenesis inhibitors.







HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
THE ONCOLOGIST STEM CELLS CME ALPHAMED PRESS JOURNALS


Copyright © 2008 by AlphaMed Press.