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First Published Online November 5, 2008
The Oncologist, Vol. 13, No. 11, 1193-1200, November 2008; doi:10.1634/theoncologist.2008-0188
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 Angiogenesis Inhibition in Non-GIST Soft Tissue Sarcomas
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Sarcomas

Angiogenesis Inhibition in Non-GIST Soft Tissue Sarcomas

Stefan Sleijfera, Winette T.A. van der Graafb, Jean-Yves Blayc

aErasmus University Medical Center, Rotterdam, The Netherlands; bRadboud University Nijmegen Medical Center, Nijmegen, The Netherlands; cCentre Léon Bérard, Lyon, France

Key Words. Soft tissue sarcoma • Angiogenesis • Vascular endothelial growth factor (VEGF)

Correspondence: Stefan Sleijfer, M.D., Ph.D., Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands. Telephone: 31-10-7041733; Fax: 31-10-7041003; e-mail: s.sleijfer{at}erasmusmc.nl

Received August 22, 2008; accepted for publication October 1, 2008; first published online in THE ONCOLOGIST Express on November 5, 2008.

Disclosure: Employment/leadership position: None; Intellectual property rights/inventor/patent holder: None; Consultant/advisory role: Jean-Yves Blay, GlaxoSmithKline; Honoraria: None; Research funding/contracted research: Stefan Sleijfer, noncommercial interest; Ownership interest: None; Expert testimony: None; Other: None.

The authors disclose that the article discusses unlabeled, investigational, or alternative use(s) of: pazopanib (GlaxoSmithKline), antiangiogenic; sorafenib (Bayer), antiangiogenic; sunitinib (Pfizer), antiangiogenic.

The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the authors, planners, independent peer reviewers, or staff managers.

Because angiogenesis is of crucial importance in the pathogenesis of cancer, blocking the function of proangiogenic factors has been shown to improve the outcomes of patients with several cancer types. Given the poor survival durations of patients with advanced soft-tissue sarcomas (STSs), which has remained stable at a median of 12 months over the last 20 year, there is an unmet need for novel agents active against these tumors. Like in other tumors, accumulating evidence points at an important role for angiogenic factors in STSs, rendering these factors attractive treatment targets. This review discusses the currently available evidence supporting a role for angiogenic factors in the pathogenesis of STSs and the first preliminary study results obtained with angiogenesis inhibitors.






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