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The Oncologist, Vol. 13, No. 2, 152-156, February 2008; doi:10.1634/theoncologist.2006-0180
© 2008 AlphaMed Press

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Neuro-Oncology

Case Report: An Unusual Case of Adrenal Neuroblastoma in Pregnancy

Marwan M. Refaata, Shereene Z. Idrissb, Lawrence S. Blaszkowskya,c

aDepartment of Medicine, bDepartment of Dermatology, and cDivision of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA

Key Words. Adrenal • Adult • Neuroblastoma • Pregnancy

Correspondence: Marwan Refaat, M.D., Massachusetts General Hospital, Department of Medicine, GRB 740, 55 Fruit Street, Boston, Massachusetts 02114, USA. Telephone 617-726-2862; Fax: 617-724-7441; e-mail: rifaatmarwan{at}hotmail.com

Disclosure: No potential conflicts of interest were reported by the authors, planners, reviewers, or staff managers of this article.

Neuroblastomas are the fourth most common malignancy of childhood and account for most adrenal tumors in children. However, they are rarely reported in adults. We present herein an extremely rare case of adrenal neuroblastoma occurring in a 25-year-old woman during her first trimester of pregnancy. She had a spontaneous abortion secondary to chorioamnionitis and she was operated on for an "incidentaloma." Her tumor was curatively resected. She presented with right lower quadrant abdominal pain 26 months after her operation and there was evidence of local tumor recurrence without metastasis. Adult adrenal neuroblastoma is an uncommon malignancy and, to our knowledge, there was no case of this tumor occurring in pregnancy ever described in the English literature. The case presentation is followed by a general discussion with an emphasis on the diagnosis, treatment, and follow-up of neuroblastoma and its association with pregnancy.






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