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The Oncologist, Vol. 13, No. 6, 700-708, June 2008; doi:10.1634/theoncologist.2007-0196
© 2008 AlphaMed Press

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Radiation Oncology

Modern Radiotherapy as Part of Combined Modality Treatment in Locally Advanced Non-Small Cell Lung Cancer: Present Status and Future Prospects

Jan P. van Meerbeecka, Sabine Meersschoutb, Rebecca De Pauwa, Indira Madanib, Wilfried De Neveb

Departments of aRespiratory Medicine and bRadiation Oncology, Lung Oncological Network Ghent (LONG), University Hospital, Ghent, Belgium

Key Words. Lung cancer • Radiotherapy • IMRT • Stage III • Chemoradiotherapy

Correspondence: Jan P. van Meerbeeck, M.D., Ph.D., Department of Respiratory Medicine, 7K12 IE, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Telephone: 329332-2611; Fax: 329332-2341; e-mail: jan.vanmeerbeeck{at}ugent.be

Received October 16, 2007; accepted for publication April 17, 2008.

Disclosure: No potential conflicts of interest were reported by the authors, planners, reviewers, or staff managers of this article.

Locally advanced stages account for approximately one third of the incident presentations of non-small cell lung cancer (NSCLC). Optimal treatment in selected patients consists of an integration of chemotherapy and radiation therapy. Both modalities have seen numerous advances in the last decade. This article reviews the current status and outcome of treatment in stage III NSCLC, with special emphasis on the role of novel techniques in radiation treatment, including intensity-modulated radiation therapy. The obstacles for improving local control are identified and the technical progress that aims at removing these obstacles is addressed.




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