This Article Full Text Full Text (PDF) eLetters: Submit a response to this article Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services E-mail this article link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Auclerc, G. Articles by Khayat, D. Search for Related Content PubMed PubMed Citation Articles by Auclerc, G. Articles by Khayat, D.

Management of Advanced Prostate Cancer

^a SOMPS, Salpêtrière Hospital, Department of Medical Oncology, Paris, France; ^b Centre Charlebourg, la Garenne-Colombes, France

Correspondence: Gerald Auclerc, M.D., Salpêtrière Hospital, Department of Medical Oncology, 47 Boulevard de l'Hôpital, 75013 Paris, France. Telephone: 33-1-4216-0474; Fax: 33-1-4336-4841.

Most cases of advanced carcinoma of the prostate are hormonosensitive. The use of combined androgen blockade (CAB) seems to improve survival and quality of life, but only when combined with chemical castration by luteinizing-hormone-releasing hormone analog and without the use of steroidal antiandrogens. After CAB, further hormonal treatments remain efficacious, such as antiandrogen withdrawal followed by estrogens, aromatase inhibitors, and hormone-refractory prostate cancer multiple cytotoxic agents. For painful bone lesions, external beam radiotherapy, biphosphonates, and strontium 89 or samarium 153 provide pain relief. The use of new methods for the evaluation of response and quality of life will allow the rapid identification of effective treatments and permit powered phase III trials.

Key Words. Advanced prostate cancer • Hormonal therapy • Hormone resistance • Irradiation • Chemotherapy • Quality-of-life evaluation

This article has been cited by other articles:

				G. Di Lorenzo, G. Tortora, F. P. D'Armiento, G. De Rosa, S. Staibano, R. Autorino, M. D'Armiento, M. De Laurentiis, S. De Placido, G. Catalano, et al. Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer Clin. Cancer Res., November 1, 2002; 8(11): 3438 - 3444. [Abstract] [Full Text] [PDF]

				Z. Weihua, R. Lathe, M. Warner, and J.-A. Gustafsson An endocrine pathway in the prostate, ERbeta , AR, 5alpha -androstane-3beta ,17beta -diol, and CYP7B1, regulates prostate growth PNAS, October 15, 2002; 99(21): 13589 - 13594. [Abstract] [Full Text] [PDF]

				S. C. Dixon, K. B. Knopf, and W. D. Figg The Control of Prostate-Specific Antigen Expression and Gene Regulation by Pharmacological Agents Pharmacol. Rev., March 1, 2001; 53(1): 73 - 92. [Abstract] [Full Text] [PDF]