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Childhood Cancers: Hepatoblastoma

University of Texas M.D. Anderson Cancer Center, University of Texas-Houston Medical School, Houston, Texas, USA

Correspondence: Cynthia E. Herzog, M.D., University of Texas M.D. Anderson Cancer Center, University of Texas-Houston Medical School, 1515 Holcombe Blvd., Houston, Texas 77030, USA. Telephone: 713-745-0157; Fax 713-792-0608; e-mail: cherzog{at}mdanderson.org

Hepatoblastoma is the most common primary liver tumor in children, accounting for just over 1% of pediatric cancers. The etiology is unknown, but it has been associated with Beckwith-Weidemann syndrome, familial adenomatosis polypi, and low birth weight. The primary treatment is surgical resection, however, chemotherapy plays an important role by increasing the number of tumors that are resectable. The prognosis for patients with resectable tumors is fairly good, however, the outcome for those with nonresectable or recurrent disease is poor.

Key Words. Hepatoblastoma • Liver • Alpha-fetoprotein