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Clinical Trials of Arsenic Trioxide in Hematologic and Solid Tumors: Overview of the National Cancer Institute Cooperative Research and Development Studies

Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA

Correspondence: Anthony J. Murgo, M.D., Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, 6130 Executive Blvd., EPN Suite 7131, Rockville, Maryland, 20852-4910, USA. Telephone: 301-496-1196; Fax: 301-402-0428; e-mail: Murgoa{at}ctep.nci.nih.GOV

Arsenic trioxide inhibits growth and promotes apoptosis in many different cancer cell lines. The National Cancer Institute is working cooperatively with research centers across the U.S. to evaluate its clinical activity in hematologic malignancies, such as acute promyelocytic leukemia, acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, chronic lymphocytic leukemia, myelodysplastic syndrome, and multiple myeloma. It is also supporting research in solid tumors, such as advanced hormone-refractory prostate cancer and renal cell cancer and in cervical cancer and refractory transitional cell carcinoma of the bladder. The safety and pharmacokinetics of arsenic trioxide are also being evaluated in pediatric patients with refractory leukemia and lymphoma. The results of these ongoing studies should provide important insights into the clinical utility of arsenic trioxide in these diseases.

Key Words. Arsenic trioxide • National Cancer Institute • Hematologic malignancy • Solid tumor

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