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Molecular Aspects of the Mammalian Cell Cycle and Cancer

Department of Anatomy and Cell Biology, University of Bergen, Bergen, Norway

Correspondence: T. Sandal, Ph.D., Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, 5009 Bergen, Norway. Telephone: 47-5-558-6375; Fax: 47-5-558-6360; e-mail: tone.sandal{at}iac.uib.no

Cancer arises mainly from mutations in somatic cells. However, it is not the result of a single mutation, rather, it results from increasing genetic disarray accumulated over time. Tumorigenesis in humans is, therefore, a multistep and age-dependent process.

The multiple mechanisms and multiple players involved in this process necessitate an understanding of the molecular mechanisms, in order to distinctively classify the tumor sample and to assess the risk and treatment of the disease.

Key Words. Cell cycle • Cancer • G₁/S-transition • Retinoblastoma • Cyclin dependent kinases

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