| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
Correspondence: Alexander I. Spira, M.D., Ph.D., Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Building, Room G88, 1650 Orleans Street, Baltimore, Maryland 21231-1000, USA. Telephone: 410-614-3746; Fax: 410-614-9424; e-mail: spiraal{at}jhmi.edu
The treatment of advanced soft-tissue sarcomas is often palliative, although a subset of patients may be cured or have a long disease-free interval. This paper reviews the historical data over 30 years of treatment that has led to the use of ifosfamide and doxorubicin as the mainstay in the treatment of metastatic disease. These treatments have a high toxicity, relative to other chemotherapeutic regimens, with median response durations on the order of months. Agents developed in the last few years, whose role in the treatment of sarcomas is still evolving, are discussed as well. Finally, we discuss the role of chemotherapy in combination with surgery and radiation in the adjuvant and neoadjuvant settings.
This article has been cited by other articles:
![]() |
G. D. Demetri, S. P. Chawla, M. von Mehren, P. Ritch, L. H. Baker, J. Y. Blay, K. R. Hande, M. L. Keohan, B. L. Samuels, S. Schuetze, et al. Efficacy and Safety of Trabectedin in Patients With Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide: Results of a Randomized Phase II Study of Two Different Schedules J. Clin. Oncol., September 1, 2009; 27(25): 4188 - 4196. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Ren, B. Korchin, Q.-S. Zhu, C. Wei, A. Dicker, J. Heymach, A. Lazar, R. E. Pollock, and D. Lev Epidermal Growth Factor Receptor Blockade in Combination with Conventional Chemotherapy Inhibits Soft Tissue Sarcoma Cell Growth In vitro and In vivo Clin. Cancer Res., May 1, 2008; 14(9): 2785 - 2795. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Kilickap, M. Cakar, I. K Onal, A. Tufan, H. Akoglu, S. Aksoy, M. Erman, and G. Tekuzman Nonconvulsive Status Epilepticus Due to Ifosfamide Ann. Pharmacother., February 1, 2006; 40(2): 332 - 335. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| THE ONCOLOGIST | STEM CELLS | CME | ALPHAMED PRESS JOURNALS |