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ZD1839 (Iressa^TM): For More Than Just Non-Small Cell Lung Cancer

Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom

Correspondence: Malcolm Ranson, M.D., Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK, M20 4BX. Telephone: 44-0-161-446-3000; Fax: 44-0-161-446-3299; e-mail: malcolm.ranson{at}man.ac.uk

ZD1839 (Iressa^TM) is an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor that blocks signal transduction pathways involved in cell proliferation. Preclinical studies demonstrated that ZD1839 is a promising agent for the treatment of a wide range of tumors and has additive-to-synergistic effects when combined with radiation or chemotherapy in various cell lines and xenografts. Phase I clinical trials have reported that ZD1839 has acceptable tolerability and antitumor activity. In addition to non-small cell lung cancer, phase II/III studies are currently investigating ZD1839 as monotherapy or in combination therapy against prostate, breast, head and neck, gastric, and colorectal tumors.

Key Words. ZD1839 (Iressa^TM) • Breast cancer • Prostate cancer • Head and neck cancer • Colorectal cancer

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