This Article Full Text Full Text (PDF) eLetters: Submit a response to this article Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services E-mail this article link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints/Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Khan, M. A. Articles by Partin, A. W. Search for Related Content PubMed PubMed Citation Articles by Khan, M. A. Articles by Partin, A. W.

Management of High-Risk Populations with Locally Advanced Prostate Cancer

James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Correspondence: Alan W. Partin, M.D., Ph.D., James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Jefferson Building Room 157, 600 North Wolfe Street, Baltimore, Maryland 21287-2101, USA. Telephone: 410-614-4876; Fax: 410-614-8096; e-mail: apartin{at}jhmi.edu

Prostate cancer that extends beyond the confines of the prostatic gland on clinical and/or radiographic assessment, without evidence of lymph node or distant metastases, is regarded as locally advanced. The locally advanced prostate cancer patient population consists of a heterogeneous group of men, some of whom have tumors that may be amenable to primary curative intent with local definitive therapy associated with acceptable long-term cancer control rates. In order to optimally manage this group of patients, it is important to be able to recognize who is at a high risk of tumor recurrence after primary local therapy. In this brief review, we discuss the factors that contribute to the prediction of high risk in populations with locally advanced disease and the treatment options available.

Key Words. Locally advanced prostate cancer • Risk factors • Management

This article has been cited by other articles:

				L. Wang, H. Hricak, M. W. Kattan, H.-N. Chen, P. T. Scardino, and K. Kuroiwa Prediction of Organ-confined Prostate Cancer: Incremental Value of MR Imaging and MR Spectroscopic Imaging to Staging Nomograms Radiology, December 12, 2005; (2005) 2382041905. [Abstract] [Full Text]

				R. W. Veltri, M. A. Khan, M. C. Miller, J. I. Epstein, L. A. Mangold, P. C. Walsh, and A. W. Partin Ability to Predict Metastasis Based On Pathology Findings and Alterations in Nuclear Structure Of Normal-Appearing and Cancer Peripheral Zone Epithelium in the Prostate Clin. Cancer Res., May 15, 2004; 10(10): 3465 - 3473. [Abstract] [Full Text] [PDF]