The Oncologist, Vol. 11, No. 10, 1134, November 2006; doi:10.1634/theoncologist.11-10-1134
© 2006 AlphaMed Press
In Reply
Merih Guray,
Aysegul Sahin
University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Correspondence:
Aysegul Sahin, M.D., University of Texas M. D. Anderson Cancer Center, Unit 85, 1515 Holcombe Boulevard, Houston, Texas 77030, USA. Telephone: 713-794-1500; Fax: 713-745-5704; e-mail: asahin{at}mdanderson.org
Received July 17, 2006;
accepted for publication September 13, 2006.
We would like to thank Drs. Mannello and Tonti for their kind comments on our review "Benign Breast Diseases: Classification, Diagnosis, and Management." We completely agree with their comments that fibrocystic changes of the breast constitute the most frequently seen disorder in women. As the authors have mentioned, the most important aspect of these changes is the breast cancer risk associated with them. Breast cysts, which are considered as nonproliferative lesions of fibrocystic changes, are very frequently seen in the female breast. Although there seem to be two distinct subtypes of breast cysts, namely, type 1 and type 2, as Mannello et al.[1] have clearly pointed out in their review, to date there is no definitive study demonstrating which type of cyst is more prone to develop breast cancer. Nevertheless, different molecular, hormonal, and morphologic characteristics of these cysts, which are nicely summarized in the same manuscript, encourage the classification of these lesions as such. We agree that both morphologic evaluation of cysts and biochemical analysis of cyst contents are important in the classification of these lesions.
In our review, because of publication restrictions, this topic may not have been covered completely. Furthermore, the main aim of our manuscript was to cover most of the benign lesions of the breast in order to aid the practicing physician. Again, we would like to thank Drs. Mannello and Tonti for their invaluable comments and contributions to our review.
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DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST
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The authors indicate no potential conflicts of interest.
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REFERENCE
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- Mannello F, Tonti GAM, Papa S. Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies. Breast Cancer Res Treat 2006;97:115–129.[CrossRef][Medline]
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