Editor's Note

January 31, 2008:

The Editors asked the authors of "CT Screening for Lung Cancer: Update 2007" to verify they have no conflict(s) of interest. This article is not available for CME.

On April 14, 2008, the authors provided the information reported below.

General Electric: Dr. Henschke is a co-inventor on a patent and other pending patents owned by Cornell Research Foundation (CRF) which are non-exclusively licensed and related to General Electric for technology involving computer-aided diagnostic methods, including measurement of nodules. She receives royalties from CRF pursuant to Cornell policy, which in turn is consistent with the Bayh-Dole Act. None of the GE products were required for any of the research reported in this article.

NCI: Dr. Henschke is compensated for serving as a study section member for NCI.

Dr. Henschke also receives research support in the form of grants and contracts from: American Legacy Foundation, Flight Attendants' Medical Research Institute, NCI, AstraZeneca, Inc., Carestream Health, Inc. The research supported by these entities is not reported in this article.

The following projects discussed in The Oncologist received support from:

ELCAP: National Institutes of Health R01-CA-63393 and R01-CA-78905, Eastman-Kodak Corporation and General Electric Corporation

NY-ELCAP: The City of New York, Department of Health and Mental Hygiene, The Starr Foundation, Empire Blue Cross and Blue Shield, The New York Community Trust, New York State Office of Science, Technology and Academic Research (NYSTAR), The Dorothy R. Cohen Foundation, The Rogers Family Fund, Ernest E. Stempel Foundation, American Cancer Society, Weill Medical College of Cornell University, Cornell University, AMDeC Foundation, Inc., New York - Presbyterian Hospital

I-ELCAP: Department of Energy DE-FG02-96SF21260; Department of Defense Grant; STAR); Israel Cancer Association; Foundation for Early Detection of Lung Cancer; The Foundation for Lung Cancer: Early Detection, Prevention, and Treatment (primary source of funding was an unrestricted gift by the Vector Group, the parent company of Liggett Tobacco); Research Foundation of Clinic Hirslanden; Yad- Hanadiv Foundation; Jacob and Malka Goldfarb Charitable Foundation; Auen/Berger Foundation; Princess Margaret Foundation; Berger Foundation; Tenet Healthcare Foundation; Clinic Hirslanden; Swedish Hospital; Christiana Care Helen F. Graham Cancer Center; Holy Cross Hospital; Eisenhower Hospital; Jackson Memorial Hospital Health System; Evanston Northwestern Healthcare

The following is a listing of the patent and patent applications in which Claudia Henschke is listed as a co-inventor.

1) U.S. Patent No. 7,274,810 "System and Method for Three-Dimensional Image Rendering and Analysis" (Patent Issued to CRF September 25, 2007); CRF has two pending divisional applications related to this Patent.
2) CRF has two pending patent applications for System, Method and Apparatus for Small Pulmonary Nodule Computer Aided Diagnosis from Computed Tomography Scans"
3) CRF has a pending patent application for "System and Method for Providing Remote Analysis of Medical Data"
4) CRF has a pending patent application for "System and Method for Analyzing Medical Data to Determine Diagnosis and Treatment"
5) CRF has a pending patent application for "System and Method for Conducting a Clinical Trial Study"
6) CRF has a pending PCT application for "Medical Imaging Visibility Index System and Method for Cancer Lesions"
7) CRF has a pending patent application (and foreign pending patent applications) for "Method for Expanding the Domain of Imaging Software in a Diagnostic Workup"
8) CRF has a pending patent application for "System and Method for Position Matching of a Patient for Medical Imaging"
9) Dr. Henschke is an inventor on a pending patent application for Medical Imaging System for Accurate Measurement Evaluation of Changes in a Target Lesion (foreign patent applications also pending)

Dr. Yankelevitz has the following relationships with PneumRx, Inc. and with General Electric.

PneumRX, Inc.: Dr. Yankelevitz is an inventor on a pending patent related to biopsy needles assigned to PneumRX,Inc., a paid medical advisor, and holds stock in the company.

General Electric: Dr. Yankelevitz is a co-inventor on a patent and other pending patents owned by Cornell Research Foundation (CRF) which are non-exclusively licensed and related to technology involving computer-aided diagnostic methods, including measurement of nodules. He receives royalties from CRF pursuant to Cornell policy, which in turn is consistent with the Bayh-Dole Act.

Receives research support in the form of grants and contracts from: American Legacy Foundation, Flight Attendants' Medical Research Institute, NCI, AstraZeneca, Inc., OSI Pharmaceutical, GlaxoSmithKline, Visiongate, Carestream Health, Inc.. The research supported by these entities is not reported in this article.

Research support for the projects reported in The Oncologist are given in Dr. Henschke’s disclosure.

The following is a listing of the patent and patent applications in which David Yankelevitz is listed as a co-inventor.

1) U.S. Patent No. 7,274,810 "System and Method for Three-Dimensional Image Rendering and Analysis" (Patent Issued to CRF September 25, 2007); CRF has two pending divisional applications related to this Patent.
2) CRF has two pending patent applications for System, Method and Apparatus for Small Pulmonary Nodule Computer Aided Diagnosis from Computed Tomography Scans"
3) CRF has a pending patent application for "System and Method for Providing Remote Analysis of Medical Data"
4) CRF has a pending patent application for "System and Method for Analyzing Medical Data to Determine Diagnosis and Treatment"
5) CRF has a pending patent application for "System and Method for Conducting a Clinical Trial Study"
6) CRF has a pending PCT application for "Medical Imaging Visibility Index System and Method for Cancer Lesions"
7) CRF has a pending patent application (and foreign pending patent applications) for "Method for Expanding the Domain of Imaging Software in a Diagnostic Workup"
8) CRF has a pending patent application for "System and Method for Position Matching of a Patient for Medical Imaging"
9) Dr. Yankelevitz is an inventor on a pending patent application for Medical Imaging System for Accurate Measurement Evaluation of Changes in a Target Lesion (foreign patent applications also pending)