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Letters to the Editor

In Reply

Department of Radiology, New York Presbyterian Hospital, Weill Medical College, New York, New York, USA

Correspondence: Claudia I. Henschke, Ph.D., M.D., Department of Radiology, New York Presbyterian Hospital-Weill Medical College, 525 East 68th Street, New York, New York 10065, USA. Telephone: 212-746-2529; Fax: 212-746-2811; e-mail: chensch{at}med.cornell.edu

Received August 7, 2008; accepted for publication August 7, 2008.

Disclosure: Dr. Henschke has the following relationships with General Electric and the National Cancer Institute (NCI).

General Electric: Dr. Henschke is a coinventor on a patent and other pending patents owned by Cornell Research Foundation (CRF) which are nonexclusively licensed and related to General Electric for technology involving computer-aided diagnostic methods, including measurement of nodules. She receives royalties from CRF pursuant to Cornell policy, which in turn is consistent with the Bayh-Dole Act.

NCI: Dr. Henschke is compensated for serving as a study section member for NCI.

Dr. Henschke also receives research support in the form of grants and contracts from: American Legacy Foundation, Flight Attendants' Medical Research Institute, NCI, AstraZeneca, Inc., Carestream Health, Inc., and the Foundation for Lung Cancer: early detection, prevention and treatment (primary source of funding was an unrestricted gift by the Vector group, the parent company of Liggett Tobacco).

The following is a listing of the patent and patent applications in which Claudia Henschke is listed as a coinventor.

1. U.S. Patent No. 7,274,810 "System and Method for Three-Dimensional Image Rendering and Analysis" (Patent issued to CRF September 25, 2007); CRF has two pending divisional applications related to this patent.
   
2. CRF has two pending patent applications for "System, Method and Apparatus for Small Pulmonary Nodule Computer Aided Diagnosis from Computed Tomography Scans."
   
3. CRF has a pending patent application for "System and Method for Providing Remote Analysis of Medical Data."
   
4. CRF has a pending patent application for "System and Method for Analyzing Medical Data to Determine Diagnosis and Treatment."
   
5. CRF has a pending patent application for "System and Method for Conducting a Clinical Trial Study."
   
6. CRF has a pending PCT application for "Medical Imaging Visibility Index System and Method for Cancer Lesions."
   
7. CRF has a pending patent application (and foreign pending patent applications) for "Method for Expanding the Domain of Imaging Software in a Diagnostic Workup."
   
8. CRF has a pending patent application for "System and Method for Position Matching of a Patient for Medical Imaging."
   
9. Dr. Henschke is an inventor on a pending patent application for "Medical Imaging System for Accurate Measurement Evaluation of Changes in a Target Lesion"(foreign patent applications also pending).
   

Dr. Bach raised issue about our recent review article in The Oncologist in which we address the concerns that some may have regarding overdiagnosis [1]. I have addressed his particular concern regarding classification of the untreated stage I cases of lung cancer recently [2] and acknowledge the same reclassification issue with the five additional cases of this kind reported in The Oncologist. I agree with Dr. Bach that this is one of many important analytic issues intrinsic to lung cancer screening research.

	REFERENCES

Top References

 

1. Henschke CI, Yankelevitz DF. CT screening for lung cancer: Update 2007. The Oncologist 2008;13:65–78.[Abstract/Free Full Text]
2. Henschke C. Clarifying Enrollment Procedures in the Trial of CT Screening for Lung Cancer. N Engl J Med 2008;359:871–873.[Free Full Text]

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