help button home button The Oncologist
HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow eLetters: Submit a response to this article
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Portenoy, R. K.
Right arrow Articles by Itri, L. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Portenoy, R. K.
Right arrow Articles by Itri, L. M.
The Oncologist, Vol. 4, No. 1, 1-10, February 1999
© 1999 AlphaMed Press

Cancer-Related Fatigue: Guidelines for Evaluation and Management

Russell K. Portenoya, Loretta M. Itrib

a Beth Israel Medical Center, New York, New York; b Ortho Biotech Inc., Raritan, New Jersey, USA

Correspondence: Russell K. Portenoy, M.D., Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, New York 10003, USA. Telephone: 212-844-1505; Fax: 212-844-1503; e-mail: RPortenoy{at}BethIsraelNY.org


   Abstract
Top
 Abstract
Introduction
 Definition, Prevalence, and...
 Evaluation of Fatigue
 Management Strategies
 Summary
 References
 
Fatigue is a highly prevalent condition among cancer patients. Although most cancer patients report that fatigue is a major obstacle to maintaining normal daily activities and quality of life, it is seldom assessed and treated in clinical practice. Few studies have explored its epidemiology, possible etiologies, or management. Cancer-related fatigue, which recently was accepted as a diagnosis in the International Classification of Diseases 10th Revision-Clinical Modification, reduces physical, psychological, and social functioning and results in significant distress for patients and caregivers. Adequate evaluation of fatigue must do more than simply assess severity. The assessment should clarify other characteristics, determine the degree to which fatigue interferes with the activities of daily living, and identify potential causes, including the underlying disease, disease treatments, intercurrent systemic disorders, psychological disorders, and other conditions. Possible primary therapies include modification of the patient's drug regimen, correction of metabolic abnormalities, and pharmacologic treatments for anemia (e.g., epoetin alfa), depression, or insomnia. Other symptomatic interventions include specific drug treatments, exercise, modification of activity and rest patterns, cognitive therapies, sleep hygiene approaches, and nutritional support. Pharmacologic approaches, which are supported by limited studies and growing clinical experience, include psychostimulant drugs, corticosteroids, and possibly other therapies. Although additional research is needed to further identify the causes and corresponding treatment of fatigue, practitioners should routinely assess and treat patients who may benefit from currently identified interventions, because fatigue can profoundly undermine the quality of life of patients with cancer.

Key Words. Fatigue • Cancer • Quality of life • Anemia • Erythropoietin (EPO) • Epoetin alfa • Asthenia


   Introduction
Top
 Abstract
 Introduction
Definition, Prevalence, and...
 Evaluation of Fatigue
 Management Strategies
 Summary
 References
 
Fatigue has been identified by patients with cancer as a major obstacle to normal functioning and a good quality of life [1]. It is a nearly universal symptom in patients undergoing primary antineoplastic therapy or treatment with biologic response modifiers and is extremely common in populations with persistent or advanced disease [1-12].

Given the prevalence and impact of cancer-related fatigue, there have been remarkably few studies of the phenomenon. Its epidemiology has been poorly defined, and the variety of clinical presentations remains anecdotal. The existence of discrete fatigue syndromes linked with predisposing factors or potential etiologies has not been confirmed, and clinical trials to evaluate putative therapies for specific types of cancer-related fatigue are almost entirely lacking.

It is important to begin to characterize the phenomenon of cancer-related fatigue and offer guidelines for management. Increased awareness will encourage better assessment and consideration of available therapeutic options. Management will improve as new research clarifies the prevalence and nature of the problem, yields validated assessment tools, and evaluates specific treatment strategies. This review discusses the clinical aspects of cancer-related fatigue and offers strategies to assist in the management of this undertreated condition.


   Definition, Prevalence, and Causes of Fatigue
Top
 Abstract
 Introduction
 Definition, Prevalence, and...
Evaluation of Fatigue
 Management Strategies
 Summary
 References
 
Patients and practitioners can generally differentiate "normal" fatigue experienced by the general population from clinical fatigue associated with cancer or its treatment. The term "asthenia" has been used to describe fatigue in oncology patients but has no specific meaning apart from the more common term. Fatigue is an inherently subjective and multidimensional condition. It may be described in terms of a variety of characteristics (e.g., severity, distress, temporal features) and specific impairments (e.g., lack of energy, weakness, somnolence, difficulty concentrating). Criteria have been needed to define this clinically relevant syndrome. Recently, cancer-related fatigue was accepted as a diagnosis in the International Classification of Diseases 10th Revision-Clinical Modification. Fatigue may be characterized as a multidimensional phenomenon that develops over time, diminishing energy, mental capacity, and the psychologic condition of cancer patients ( Table 1) [13]. Fatigue is also linked with lethargy, malaise, and asthenia in the revised National Cancer Institute (NCI) Common Toxicity Criteria (CTC). These classifications may enhance awareness of fatigue and improve reporting of the condition.


View this table:
[in this window]
[in a new window]
  		Table 1. Proposed criteria for cancer-related fatigue [13]
 
Cancer-related fatigue is extremely prevalent. A recent population-based survey of 419 randomly selected patients observed that 78% experienced fatigue, which was defined as debilitating tiredness or loss of energy at least once each week; the majority of these patients reported that fatigue had either significantly (31%) or somewhat (39%) affected their daily routine [1]. In a cross-sectional survey of 151 ovarian cancer patients, the prevalence of fatigue was 69%, and approximately half of affected patients described the condition as highly distressing [11]. Other surveys of patients with metastatic disease suggest that the prevalence in this setting exceeds 75% [11, 14-18].

Numerous surveys have associated the occurrence of fatigue with specific treatments [3-6, 19-23]. These surveys suggest that fatigue commonly occurs after surgery, chemotherapy, radiotherapy, or immunotherapy. Prevalence rates of fatigue as high as 96% have been reported in conjunction with chemotherapy and radiotherapy [5], and severe fatigue is almost universal with the use of biologic response modifiers, including {alpha}-interferon and the interleukins [19, 23, 24].

When fatigue is primarily related to a treatment, there is generally a clear temporal relationship between the condition and the intervention [21, 25-27]. In patients receiving cyclic chemotherapy, for example, fatigue often peaks within a few days and declines until the next treatment cycle. During a course of fractionated radiotherapy, fatigue is often cumulative and may peak after a period of weeks. Occasionally, fatigue persists for a prolonged period beyond the end of chemotherapy or radiotherapy.

The relationships between fatigue and demographic characteristics, physiologic factors, and psychosocial factors are not well defined. The specific mechanisms that precipitate or sustain the syndrome are unknown. Fatigue may represent a final common pathway to which many predisposing or etiologic factors contribute ( Table 2) [29-35]. The pathophysiology in any individual may be multifactorial. Proposed mechanisms include abnormalities in energy metabolism related to increased requirements (e.g., due to tumor growth, infection, fever, or surgery); decreased availability of metabolic substrate (e.g., due to anemia, hypoxemia, or poor nutrition); or the abnormal production of substances that impair metabolism or normal functioning of muscles (e.g., cytokines or antibodies). Other proposed mechanisms link fatigue to the pathophysiology of sleep disorders and major depression. There is no clear evidence in support of any of these mechanisms, and further research is needed.


View this table:
[in this window]
[in a new window]
  		Table 2. Potential predisposing factors or etiologies of cancer-related fatigue [28]
 

   Evaluation of Fatigue
Top
 Abstract
 Introduction
 Definition, Prevalence, and...
 Evaluation of Fatigue
Management Strategies
 Summary
 References
 
Assessment of Fatigue Characteristics
A detailed characterization of fatigue, coupled with an understanding of the most likely etiologic factors, is necessary to develop a therapeutic strategy ( Table 3). A comprehensive assessment includes a description of fatigue-related phenomena, a physical examination, and a review of laboratory and imaging studies. These data may allow plausible hypotheses concerning pathogenesis, which in turn may suggest appropriate treatment strategies.


View this table:
[in this window]
[in a new window]
  		Table 3. Evaluation of cancer-related fatigue
 
Patients may describe fatigue in terms of decreased vitality or lack of energy, muscular weakness, dysphoric mood, somnolence, impaired cognitive functioning, or some combination of these disturbances. Although this variability suggests the existence of fatigue subtypes, this has not yet been empirically confirmed. Regardless, the patient's history should clarify the spectrum of complaints and attempt to characterize features associated with each component. This information may suggest specific etiologies (e.g., depression) and influence the choice of therapy. Neurologic and psychologic evaluations also may help further clarify potential etiologies of fatigue in some patients.

Other characteristics are similarly important. Onset and duration, for example, distinguish acute and chronic fatigue. Acute fatigue has a recent onset and is anticipated to end in the near future. Chronic fatigue has persisted for a prolonged period (weeks to months, or longer) and is not expected to remit soon. Patients perceived to have chronic fatigue typically require a more intensive evaluation, as well as a management approach focused on both short- and long-term goals. Other important descriptors of fatigue include its severity, daily pattern, course over time, exacerbating and palliative factors, and associated distress.

To measure fatigue severity, consistent use of a simple unidimensional scale, such as a verbal rating scale (none, mild, moderate, severe) or a numeric scale (for example, a 0-10 scale, where "0" equals no fatigue and "10" equals the worst fatigue imaginable, or a 0-4 scale, as applied in the NCI CTC) are useful for monitoring changes over time [36]. Other unidimensional scales include the fatigue subscale of the Profile of Mood States [37], linear analog scales (linear analog scale assessment [LASA]) [38], and single items incorporated into symptom checklists [39-41].

Multidimensional fatigue assessment, which captures multiple characteristics and manifestations of fatigue and its impact on function, is more informative than the measurement of severity alone. In the practice setting, when time for evaluation is limited, the routine use of three simple questions may help assess fatigue severity and impact over time [36]:

Validated multidimensional questionnaires provide a more sophisticated alternative for practice, or, more commonly, for use in research settings [12, 22, 36, 42-47].

Multidimensional Assessment Tools
The first validated multidimensional instrument was the Piper Fatigue Self-Report Scale. This scale addresses the severity, distress, and impact of fatigue using a 41-item questionnaire administered as either a series of LASA or numeric scales [36]. It was developed to assess fatigue in patients receiving radiotherapy. It is both reliable and valid in this population and may also be used to assess cancer patients who are not receiving radiotherapy. Efforts continue to further refine it [48].

A 20-item scale that evaluates well-being associated with fatigue and anemia has been developed as a module of a general quality of life instrument known as the Functional Assessment of Cancer Therapy (FACT) [12, 42, 43]. The fatigue, or fatigue and anemia, subscales of this module can be used alone as brief, reliable, and valid assessments. Using this questionnaire, an association between fatigue and anemia was demonstrated in a large survey of cancer patients in community settings. Patients with hemoglobin values >12 g/dL reported significantly less fatigue, fewer nonfatigue anemia symptoms, better physical and functional well-being, and a higher overall quality of life than those with hemoglobin values <=12 g/dL [49].

Other validated multidimensional instruments are available [9, 44-47]. The Fatigue Symptom Inventory, for example, has been used in a series of studies that evaluated the severity and impact of treatment-related fatigue [44]. Investigators or clinicians who seek a detailed assessment of fatigue should review the items in these questionnaires and select the instrument that captures the fatigue-related phenomena of greatest interest.

Assessment of Related Constructs
An assessment of cancer-related fatigue also should include consideration of broader concerns, including global quality of life, symptom distress, and the goals of care. Fatigue may be only one of numerous factors that influence quality of life. Among these factors are progressive physical decline, psychological disorders, social isolation, financial concerns, and spiritual distress. Optimal care of the cancer patient includes a broad assessment of these factors and should be directed toward maintaining or enhancing quality of life.

The concept of global symptom distress is useful in characterizing patients who often have multiple symptoms concurrently [39-41]. Fatigue, pain, and psychological distress are the most prevalent symptoms across varied cancer populations [41]. Patients who report fatigue should be queried about the presence of other symptoms and the degree to which fatigue predominates as a cause of distress.

The goals of care guide all therapeutic decision making. Specific treatments may or may not be appropriate depending on the degree to which the preeminent goals relate to prolonging life, improving function, or providing comfort alone.


   Management Strategies
Top
 Abstract
 Introduction
 Definition, Prevalence, and...
 Evaluation of Fatigue
 Management Strategies
Summary
 References
 
A successful strategy should ameliorate fatigue within a broader approach to patient care. Education of the patient regarding the nature of fatigue, options for therapy, and anticipated outcomes is an essential aspect of the therapy. Unfortunately, results of a recent survey indicate that fatigue is seldom discussed by patients and their oncologists [1].

Treatment of Underlying Causes
As an initial approach to cancer-related fatigue, efforts should be made to correct potential etiologies, if possible and appropriate ( Fig. 1). This may include elimination of nonessential centrally acting drugs, treatment of a sleep disorder, reversal of anemia or metabolic abnormalities, or management of major depression. Many of these initial interventions are relatively simple and pose minimal burdens to the patient, healthcare provider, and caregiver.



View larger version (41K):
[in this window]
[in a new window]
  		Figure 1. Algorithm for the evaluation and management of cancer-related fatigue.

 
In patients with fatigue-associated major depression, treatment with an antidepressant is strongly indicated. As many as 25% of cancer patients develop major depression at some point during the illness; patients at greatest risk are those with advanced disease, uncontrolled physical symptoms (e.g., pain), or previous history of psychiatric disorder [50]. Although the relationship between depression and fatigue is not understood, they often occur together, and both adversely affect quality of life [51, 52]. Despite the high prevalence in the cancer population, depression is often underdiagnosed, and, consequently, undertreated [53, 54]. A trial with an antidepressant usually is warranted in a patient with fatigue associated with any significant degree of depressed mood, particularly if concurrent anxiety or pain exists.

Anemia may be a major factor in the development of cancer-related fatigue. Anecdotally, transfusion therapy for severe anemia often has been associated with substantial improvement in fatigue. Until the early 1980s, red blood cell transfusions were administered empirically when hemoglobin concentrations fell below 10 g/dL [55, 56] and were the primary treatment for cancer-related and chemotherapy-induced anemia. At that time, concern about the safety of the blood supply related to potential transmission of the human immunodeficiency virus prompted clinicians to alter their treatment approach [56, 57]. Without an alternative to transfusion, treatment of mild or moderate anemia was generally avoided until hemoglobin concentrations declined to more severe levels (7-8 g/dL) or the patient experienced signs and symptoms of severe anemia [55, 58]. As reticence to treat anemia increased, it was less often reported as an adverse sequela in published chemotherapy trials and received less attention in the medical literature overall.

New data demonstrate an association between chemotherapy-induced mild-to-moderate anemia and both fatigue and quality-of-life impairment. For example, combined data from 413 patients in three randomized, placebo-controlled trials of epoetin alfa, the recombinant form of human erythropoietin, reveal that treated patients experienced a significant increase in hematocrit, a reduced need for transfusion, and a significant improvement in overall quality of life. Those patients with an increase in hematocrit of >6% also demonstrated significant improvement in energy level and daily activities [59]. Additional studies in patients treated with chemotherapy and radiation therapy for a variety of hematologic and solid tumors confirm that epoetin alfa has positive effects on hemoglobin levels [60-63].

Two large, prospective, nonrandomized, multicenter community trials evaluated the effectiveness of epoetin alfa in anemia associated with cancer chemotherapy [64, 65]. In the more recent trial, Demetri et al. assessed the effectiveness of epoetin alfa as an adjunct to chemotherapy in more than 2,000 cancer patients undergoing cytotoxic chemotherapy [64]. Patients received epoetin alfa 10,000 units three times weekly for a maximum of 16 weeks. If the increase in hemoglobin level was <1.0 g/dL at four weeks, the dose was increased to 20,000 units three times weekly. Quality-of-life parameters were assessed with LASA and the FACT-Anemia instruments. Over time, patients experienced significant improvements in energy level, activity level, functional status, and overall quality of life; these improvements were independent of antitumor response and were significantly correlated with hemoglobin levels. These results were similar to the findings in the previous large, community-based study by Glaspy et al. [65].

Symptomatic Approaches

Pharmacologic Treatments
The pharmacologic therapies for fatigue associated with medical illness have not been rigorously evaluated in controlled trials. Nonetheless, there is evidence to support the use of several drug classes. Psychostimulants, such as methylphenidate, pemoline, and dextroamphetamine, have been well studied for the treatment of opioid-related somnolence and cognitive impairment [66], and depression in the elderly and medically ill [67-69]. There are no controlled studies of these drugs for cancer-related fatigue, but empiric administration may yield favorable results in some patients.

Clinical response to one drug does not necessarily predict response to the others, and sequential trials may be needed to identify the most beneficial therapy. Methylphenidate has been more extensively evaluated in the cancer population than other stimulant drugs and often is the first drug administered. Pemoline has less sympathomimetic activity than other psychostimulants but has a low risk of severe hepatotoxicity compared with similar agents [70]. It is available in a chewable formulation that can be absorbed through the buccal mucosa for patients who are unable to swallow or take oral medications.

Adverse effects associated with the psychostimulants include anorexia, insomnia, tremulousness, anxiety, delirium, and tachycardia. To ensure safety, slow and careful dose escalation should be undertaken to minimize potential adverse effects. A regimen of methylphenidate, for example, usually begins with a dose of 5-10 mg once or twice daily (morning and, if needed, midday). If tolerated, the dose is increased. Most patients appear to require less than 60 mg per day, but some require much higher doses.

Extensive anecdotal observations and very limited data from controlled trials [71, 72] support the use of low-dose corticosteroids in fatigued patients with advanced disease and multiple symptoms. Dexamethasone and prednisone are most commonly used. There have been no comparative trials.

The selective serotonin-reuptake inhibitors, secondary amine tricyclics (e.g., nortriptyline and desipramine), or bupropion are sometimes associated with the experience of increased energy that appears disproportionate to any change in mood. For this reason, these agents also have been tried empirically in nondepressed patients with fatigue. Given the limited experience in the use of these drugs for this indication, an empiric trial should be considered only in severe and refractory cases.

Amantadine has been used to treat fatigue in patients with multiple sclerosis, but it has not been studied in other patient populations. This drug is usually well tolerated, and an empiric trial may be warranted in selected patients with severe refractory cancer-related fatigue.

Nonpharmacologic Interventions
Nonpharmacologic approaches for the management of cancer-related fatigue are largely supported by favorable anecdotal experience ( Table 4). Patient preferences should be considered in the selection of one or more of these approaches.


View this table:
[in this window]
[in a new window]
  		Table 4. Nonpharmacologic interventions for the management of cancer-related fatigue
 
Education about fatigue greatly benefits some patients [73-77]. There are large individual differences in patients' preferences for information, however, and efforts to educate should be directed at the patients' educational level and readiness to learn. The use of a patient diary may help the clinician and patient discern a pattern to the fatigue or identify specific activities that are associated with increased levels. This information may be useful in developing a management plan that modifies specific activities and incorporates appropriate periods of rest [27]. For example, some patients identify a pattern that suggests the utility of scheduled brief rest periods during the day.

Some patients benefit from education about sleep hygiene. Sleep hygiene principles should be tailored to the individual patient and might include the establishment of a specific bedtime and wake time, and routine procedures prior to sleep [78]. Patients also should be instructed to avoid stimulants and central nervous system depressants prior to sleep [78]. Regular exercise performed at least 6 h before bedtime may improve sleep, whereas napping in the late afternoon or evening may worsen it.

Exercise may be beneficial in relieving fatigue [25, 77, 79-81]. This may be counterintuitive to patients, and considerable education may be needed to foster cooperation with an exercise program. There are no data that clarify the most appropriate exercise program for cancer patients with fatigue. In general, exercise should be individualized, considering such factors as the patient's age and medical condition. Anecdotally, the type of exercise that appears to be most beneficial involves rhythmic and repetitive movement of large muscle groups such as walking, cycling, or swimming. The exercise program should be initiated gradually and should include a light-to-moderate workout several days a week.

Anxiety, difficulties in coping with cancer or its treatment, or sleep disturbances may contribute to fatigue and may be ameliorated using stress reduction techniques or cognitive therapies, such as relaxation therapy, hypnosis, guided imagery, or distraction. Some patients find distraction (e.g., listening to music) or other cognitive techniques to be particularly effective when the symptom is associated with attention deficits [82, 83]. Referral to a psychologist for counseling and training in stress management techniques or cognitive therapies may be warranted in some patients.

Cancer and its treatment also can interfere with dietary intake. With aggressive approaches to management, patients' weight, hydration status, and electrolyte balance should be monitored and maintained to the extent possible [84]. Regular exercise may improve appetite and increase nutritional intake. Referral to a dietitian for nutritional guidance and suggestions for nutritional supplements may be useful.


   Summary
Top
 Abstract
 Introduction
 Definition, Prevalence, and...
 Evaluation of Fatigue
 Management Strategies
 Summary
References
 
Despite the high prevalence and distress associated with fatigue, there have been few studies of this condition, and relatively little is known about its epidemiology, etiologies, pathogenesis, and management. With growing interest in palliative care, however, there is recognition of fatigue as an important issue for research and treatment guideline development [13]. Oncologists, as well as the entire medical team, must become more aware of this problem, its impact on patient quality of life, and the various strategies that may be helpful in its treatment. Although further research is needed, many patients could benefit from more comprehensive evaluation and greater use of available interventions for cancer-related fatigue.


   References
Top
 Abstract
 Introduction
 Definition, Prevalence, and...
 Evaluation of Fatigue
 Management Strategies
 Summary
 References
 

  1. Vogelzang N, Breitbart W, Cella D et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. Semin Hematol 1997 ; 34(suppl 2) : 4 -12.[Medline]
  2. Cassileth BR, Lusk EJ, Bodenheimer BJ et al. Chemotherapeutic toxicity–the relationship between patients' pretreatment expectations and post-treatment results. Am J Clin Oncol 1985 ; 8 : 419 -425.[Medline]
  3. Greenberg DB, Sawicka J, Eisenthal S et al. Fatigue syndrome due to localized radiation. J Pain Symptom Manage 1992 ; 7 :38 -45.[Medline]
  4. Haylock PJ, Hart LK. Fatigue in patients receiving localized radiation. Cancer Nurs 1979 ; 2 :461 -467.[Medline]
  5. Irvine DM, Vincent L, Bubela N et al. A critical appraisal of the research literature investigating fatigue in the individual with cancer. Cancer Nurs 1991 ; 14 :188 -199.[Medline]
  6. Irvine D, Vincent L, Graydon JE et al. The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy: a comparison with the fatigue experienced by healthy individuals. Cancer Nurs 1994 ; 17 :367 -378.[Medline]
  7. King KB, Nail LM, Kreamer K et al. Patients' descriptions of the experience of receiving radiation therapy. Oncol Nurs Forum 1985 ; 12 :55 -61.[Medline]
  8. Knobf MT. Physical and psychologic distress associated with adjuvant chemotherapy in women with breast cancer. J Clin Oncol 1986 ; 4 :678 -684.[Abstract/Free Full Text]
  9. Kobashi-Schoot JAM, Hanewald GJFP, van Dam FSAM et al. Assessment of malaise in cancer treated with radiotherapy. Cancer Nurs 1985 ; 8 :306 -314.[Medline]
  10. Meyerowitz BE, Sparks FC, Spears IK. Adjuvant chemotherapy for breast carcinoma: psychosocial implications. Cancer 1979 ; 43 :1613 -1618.[Medline]
  11. Portenoy RK, Thaler HT, Kornblith AB et al. Pain in ovarian cancer: prevalence, characteristics, and associated symptoms. Cancer 1994 ; 74 :907 -915.[Medline]
  12. Yellen SB, Cella DF, Webster MA et al. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage 1997 ; 13 :63 -74.[Medline]
  13. Cella D, Peterman A, Passik S et al. Progress toward guidelines for the management of fatigue. Oncology 1998 ; 12 :1 -9.
  14. Curtis EB, Kretch R, Walsh TD. Common symptoms in patients with advanced cancer. J Palliat Care 1991 ; 7 :25 -29.[Medline]
  15. Dunphy KP, Amesbury BDW. A comparison of hospice and homecare patients: patterns of referral, patient characteristics and predictors of place of death. Palliat Med 1990 ; 4 :105 -111.
  16. Dunlop GM. A study of the relative frequency and importance of gastrointestinal symptoms and weakness in patients with far-advanced cancer: student paper. Palliat Med 1989 ; 4 :37 -43.
  17. Portenoy RK, Thaler HT, Kornblith AB et al. Symptom prevalence, characteristics, and distress in a cancer population. Qual Life Res 1994 ; 3 :183 -189.[Medline]
  18. Ventafridda V, DeConno F, Ripamonti C et al. Quality of life assessment during a palliative care program. Ann Oncol 1990 ; 1 :415 -420.[Abstract/Free Full Text]
  19. Dean GE, Spears L, Ferrell B et al. Fatigue in patients with cancer receiving interferon alpha. Cancer Pract 1995 ; 3 :164 -171.[Medline]
  20. Fobair P, Hoppe RT, Bloom J et al. Psychosocial problems among survivors of Hodgkin's disease. J Clin Oncol 1986 ; 4 :805 -814.[Abstract/Free Full Text]
  21. Pickard-Holley S. Fatigue in cancer patients: a descriptive study. Cancer Nurs 1991 ; 14 :13 -19.[Medline]
  22. Piper BF, Lindsey AM, Dodd MJ et al. The development of an instrument to measure the subjective dimension of fatigue. In: Funk SG, Tornquist EM, Champange MT et al, eds. Key Aspects of Comfort. Management of Pain, Fatigue and Nausea. New York: Springer Publishing Company, 1989:199-208.
  23. Skalla K, Rieger P. Fatigue. In: Rieger PT, ed. Biotherapy: Comprehensive Review. Boston: Jones and Bartlett, 1995:221-242.
  24. Piper BF, Rieger PT, Brophy L et al. Recent advances in the management of biotherapy-related side effects: fatigue. Oncol Nurs Forum 1989 ; 16(suppl 6) :27 -34.[Medline]
  25. Berger AM. Patterns of fatigue and activity and rest during adjuvant breast cancer chemotherapy. Oncol Nurs Forum 1998 ; 25 :51 -62.[Medline]
  26. Broeckel JA, Jacobsen PB, Horton J et al. Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer. J Clin Oncol 1998 ; 16 :1689 -1696.[Abstract]
  27. Richardson A, Ream E, Wilson-Barnett J. Fatigue in patients receiving chemotherapy: patterns of change. Cancer Nurs 1998 ; 21 :17 -30.[Medline]
  28. Portenoy RK, Miaskowski C. Assessment and management of cancer-related fatigue. In: Berger A, Portenoy RK, Weissman DE, eds. Principles and Practice of Supportive Oncology. Philadelphia: Lippincott-Raven, 1998:109-118.
  29. Aistars J. Fatigue in the cancer patient: a conceptual approach to a clinical problem. Oncol Nurs Forum 1987 ; 14 :25 -30.
  30. Piper BF, Lindsey AM, Dodd MJ. Fatigue mechanisms in cancer patients: developing nursing theory. Oncol Nurs Forum 1987 ; 14 :17 -23.
  31. Jacobs LA, Piper BF. The phenomenon of fatigue and the cancer patient. In: McCorkle R, Grant M, Frank-Stromberg M et al., eds. Cancer Nursing: A Comprehensive Textbook. Philadelphia: WB Saunders, 1996:1193-1210.
  32. Nail LM, Winningham M. Fatigue. In: Groenwald SL, Frogge MH, Goodman M et al, eds. Cancer Nursing: Principles and Practice. Boston: Jones and Bartlett, 1993:608-619.
  33. Piper BF. Alterations in comfort: fatigue. In: McNally JC, Somerville E, Miaskowski C et al, eds. Guidelines for Oncology Nursing Practice, 2nd ed. Philadelphia: WB Saunders, 1991:155-162.
  34. Smets EMA, Garssen B, Schuster-Uitterhoeve ALJ et al. Fatigue in cancer patients. Br J Cancer 1993 ; 68 :220 -224.[Medline]
  35. Winningham ML, Nail LM, Burke MB et al. Fatigue and the cancer experience: the state of the knowledge. Oncol Nurs Forum 1994 ; 21 :23 -35.[Medline]
  36. Piper BF. The Groopman article reviewed. Oncology 1998 ; 12 :345 -346.
  37. Cella DF, Jacobsen PB, Orav EJ et al. A brief POMS measure of distress for cancer patients. J Chronic Dis 1987 ; 40 :939 -942.[Medline]
  38. Bruera E, Chadwick S, Brenneis C et al. Methylphenidate associated with narcotics for the treatment of cancer pain. Cancer Treat Rep 1987 ; 71 :67 -70.[Medline]
  39. de Haes JCJM, van Kippenberg FCE, Neijt JP. Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br J Cancer 1990 ; 62 :1034 -1038.[Medline]
  40. McCorkle R, Young K. Development of a symptom distress scale. Cancer Nurs 1978 ; 1 :373 -378.[Medline]
  41. Portenoy RK, Thaler HT, Kornblith AB et al. The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics, and distress. Eur J Cancer 1994 ; 30A :1326 -1336.
  42. Cella DF, Tulsky DS, Gray G et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol 1993 ; 11 :570 -579.[Abstract/Free Full Text]
  43. Cella D. The Functional Assessment of Cancer Therapy-Anemia (FACT-An) scale: a new tool for the assessment of outcomes in cancer anemia and fatigue. Semin Hematol 1997 ; 34(suppl 2) :13 -19.[Medline]
  44. Hann DM, Jacobsen PB, Azzarello LM et al. Measurement of fatigue in cancer patients: development and validation of the Fatigue Symptom Inventory. Qual Life Res 1998 ; 7 :301 -310.[Medline]
  45. Lee KA, Hicks G, Nino-Murcia G. Validity and reliability of a scale to assess fatigue. Psychiatry Res 1991 ; 36 :291 -298.[Medline]
  46. Morant R, Stiefel F, Berchtold W et al. Preliminary results of a study assessing asthenia and related psychological and biological phenomena in patients with advanced cancer. Support Care Cancer 1993 ; 1 :101 -107.[Medline]
  47. Cleeland CC. Brief Fatigue Inventory (BFI), URL: http://www.qlmed.org/BFI/index.html
  48. Piper BF, Dibble SL, Dodd MJ et al. The revised Piper Fatigue Scale: psychometric evaluation in women in breast cancer. Oncol Nurs Forum 1998 ; 25 :677 -684.[Medline]
  49. Cella D. Factors influencing quality of life in cancer patients: anemia and fatigue. Semin Oncol 1998 ; 25 :43 -46.[Medline]
  50. Breitbart W. Identifying patients at risk for, and treatment of major psychiatric complications of cancer. Support Care Cancer 1995 ; 3 :45 -60.[Medline]
  51. Visser MR, Smets EM. Fatigue, depression and quality of life in cancer patients: how are they related? Support Care Cancer 1998 ; 6 :101 -108.[Medline]
  52. Dimeo F, Stieglitz RD, Novelli-Fischer U et al. Correlation between physical performance and fatigue in cancer patients. Ann Oncol 1997 ; 8 :1251 -1255.[Abstract/Free Full Text]
  53. Hardman A, Maguire P, Crowther D et al. The recognition of psychiatric morbidity on a medical oncology ward. J Psychosom Res 1989 ; 33 :235 -239.[Medline]
  54. Passik SD, Dugan W, McDonald MV et al. Oncologists' recognition of depression in their patients with cancer. J Clin Oncol 1998 ; 16 :1594 -1600.[Abstract/Free Full Text]
  55. Consensus conference. Perioperative red cell transfusion. JAMA 1988 ; 260 :2700 -2703.[Abstract/Free Full Text]
  56. Welch HG, Meehan KR, Goodnough LT. Prudent strategies for elective red blood cell transfusion. Ann Intern Med 1992 ; 116 :393 -402.
  57. Surgenor DM, Wallace EL, Hale SG et al. Changing patterns of blood transfusions in four sets of United States hospitals, 1980 to 1985. Transfusion 1988 ; 28 :513 -518.[Medline]
  58. Silberstein LE, Kruskall MS, Stehling LC et al. Strategies for the review of transfusion practices. JAMA 1989 ; 262 :1993 -1997.[Abstract/Free Full Text]
  59. Abels RI, Larholt KM, Drantz KD et al. Recombinant human erythropoietin (r-HuEPO) for the treatment of the anemia of cancer. In: Murphy MJ, ed. Blood Cell Growth Factors: Their Present and Future Use in Hematology and Oncology. Dayton: AlphaMed Press, 1992:121-141.
  60. Cascinu S, Fedeli A, Del Ferro E et al. Recombinant human erythropoietin treatment in cisplatin-associated anemia: a randomized, double-blind trial with placebo. J Clin Oncol 1994 ; 12 :1058 -1062.[Abstract/Free Full Text]
  61. Ludwig H, Fritz E, Kotzmann H et al. Erythropoietin treatment of anemia associated with multiple myeloma. N Engl J Med 1990 ; 322 :1693 -1699.[Abstract]
  62. Oster W, Hermann F, Gamm H et al. Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration. J Clin Oncol 1990 ; 8 :956 -962.[Abstract]
  63. Platanias LC, Miller CB, Mick R et al. Treatment of chemotherapy-induced anemia with recombinant human erythropoietin. J Clin Oncol 1991 ; 9 :2021 -2026.[Abstract/Free Full Text]
  64. Demetri GD, Kris M, Wade J et al. Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. J Clin Oncol 1998 ; 16 :3412 -3425.[Abstract]
  65. Glaspy J, Bukowski R, Steinberg D et al. The impact of therapy with epoetin alfa on clinical outcomes during cancer chemotherapy in community oncology practice. J Clin Oncol 1997 ; 15 :1218 -1234.[Abstract/Free Full Text]
  66. Bruera E, Brenneis C, Paterson AH et al. Use of methylphenidate as an adjuvant to narcotic analgesics in patients with advanced cancer. J Pain Symptom Manage 1989 ; 4 :3 -6.[Medline]
  67. Breitbart W, Mermelstein H. An alternative psychostimulant for the management of depressive disorders in cancer patients. Psychosomatics 1992 ; 33 :352 -356.[Free Full Text]
  68. Fernandez F, Adams F, Levy JK. Cognitive impairment due to AIDS-related complex and its response to psychostimulants. Psychosomatics 1988 ; 29 :38 -46.[Abstract/Free Full Text]
  69. Katon W, Raskind M. Treatment of depression in the medically ill elderly with methylphenidate. Am J Psychiatry 1980 ; 137 :963 -965.[Abstract/Free Full Text]
  70. Berkovitch M, Pope E, Phillips J et al. Pemoline-associated fulminant liver failure: testing the evidence for causation. Clin Pharm Ther 1995 ; 57 :696 -698.[Medline]
  71. Bruera E, Roca E, Cedaro L et al. Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Cancer Treat Rep 1985 ; 69 :751 -754.[Medline]
  72. Tannock I, Gospodarowicz M, Meakin W et al. Treatment of metastatic prostatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. J Clin Oncol 1989 ; 7 :590 -597.[Abstract]
  73. Egbert LD, Battit GE, Welch CE et al. Reduction of postoperative pain by encouragement and instruction of patients. N Engl J Med 1964 ; 207 :825 -827.
  74. Fortin F, Kirouac S. A randomized controlled trial of preoperative patient education. Int J Nurs Stud 1976 ; 13 :11 -24.[Medline]
  75. Johnson J, Fuller S, Endress MP et al. Altering patients' responses to surgery: an extension and replication. Res Nurs Health 1978 ; 1 :111 -121.[Medline]
  76. Johnson J, Rice V, Fuller S et al. Sensory information, instruction in a coping strategy, and recovery from surgery. Res Nurs Health 1978 ; 1 :4 -17.[Medline]
  77. Winningham ML. Fatigue. In: Groenwald SL, Frogge MH, Goodman M et al, eds. Cancer Symptom Management. Boston: Jones and Bartlett, 1996:42-58.
  78. Yellen SB, Dyonzak JV. Sleep disturbances. In: Groenwald SL, Frogge MH, Goodman M et al, eds. Cancer Symptom Management. Boston: Jones and Bartlett, 1996:151-168.
  79. Dimeo F, Rumberger BG, Keul J. Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exercise 1998 ; 30 :475 -478.[Medline]
  80. MacVicar SB, Winningham ML. Promoting functional capacity of cancer patients. Cancer Bull 1986 ; 38 :235 -239.
  81. Schwartz AL. Patterns of exercise and fatigue in physically active cancer survivors. Oncol Nurs Forum 1998 ; 25 :485 -491.[Medline]
  82. Cimprich B. Attentional fatigue following breast cancer surgery. Res Nurs Health 1992 ; 15 :199 -207.[Medline]
  83. Cimprich B. Developing an intervention to restore attention in cancer patients. Cancer Nurs 1993 ; 16 :83 -92.[Medline]
  84. Dalakas MC, Mock V, Hawkins MJ. Fatigue: definitions, mechanisms, and paradigms for study. Semin Oncol 1998 ; 25(suppl 1) :48 -53.[Medline]
accepted for publication January 19, 1999.




This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
M. R Cooper, H. M Bird, and M. Steinberg
Efficacy and Safety of Modafinil in the Treatment of Cancer-Related Fatigue
Ann. Pharmacother., April 1, 2009; 43(4): 721 - 725.
[Abstract] [Full Text] [PDF]

Home page
 Palliat MedHome page
L. Radbruch, F. Strasser, F. Elsner, J. F. Goncalves, J. Loge, S. Kaasa, F. Nauck, P. Stone, and the Research Steering Committee of the European As
Fatigue in palliative care patients -- an EAPC approach
Palliative Medicine, January 1, 2008; 22(1): 13 - 32.
[Abstract] [PDF]

Home page
 The OncologistHome page
J. K. Carroll, S. Kohli, K. M. Mustian, J. A. Roscoe, and G. R. Morrow
Pharmacologic Treatment of Cancer-Related Fatigue
Oncologist, May 1, 2007; 12(suppl_1): 43 - 51.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
K. M. Mustian, G. R. Morrow, J. K. Carroll, C. D. Figueroa-Moseley, P. Jean-Pierre, and G. C. Williams
Integrative Nonpharmacologic Behavioral Interventions for the Management of Cancer-Related Fatigue
Oncologist, May 1, 2007; 12(suppl_1): 52 - 67.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S.-C. Shun, S. L. Beck, M. A. Pett, and S. J. Richardson
Assessing Responsiveness of Cancer-Related Fatigue Instruments: Distribution-Based and Individual Anchor-Based Methods
Oncologist, April 1, 2007; 12(4): 495 - 504.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
S. Yennurajalingam and E. Bruera
Palliative Management of Fatigue at the Close of Life: "It Feels Like My Body Is Just Worn Out"
JAMA, January 17, 2007; 297(3): 295 - 304.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
P. Barrett-Lee, C. Bokemeyer, P. Gascon, J.W.R. Nortier, M. Schneider, D. Schrijvers, S. Van Belle, and for the Ecas Advisory Board and Participating Cent
Management of Cancer-Related Anemia in Patients with Breast or Gynecologic Cancer: New Insights Based on Results from the European Cancer Anemia Survey
Oncologist, October 1, 2005; 10(9): 743 - 757.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. Yates, S. Aranda, M. Hargraves, B. Mirolo, A. Clavarino, S. McLachlan, and H. Skerman
Randomized Controlled Trial of an Educational Intervention for Managing Fatigue in Women Receiving Adjuvant Chemotherapy for Early-Stage Breast Cancer
J. Clin. Oncol., September 1, 2005; 23(25): 6027 - 6036.
[Abstract] [Full Text] [PDF]

Home page
 J Natl Cancer Inst MonogrHome page
A. Rao and H. J. Cohen
Symptom Management in the Elderly Cancer Patient: Fatigue, Pain, and Depression
J Natl Cancer Inst Monographs, July 1, 2004; 2004(32): 150 - 157.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. Iop, A. M. Manfredi, and S. Bonura
Fatigue in cancer patients receiving chemotherapy: an analysis of published studies
Ann. Onc., May 1, 2004; 15(5): 712 - 720.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
E. Dillon and J. Kelly
The Status of Cancer Fatigue on the Island of Ireland: AIFC Professional and Interim Patient Surveys
Oncologist, February 1, 2003; 8(90001): 22 - 26.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. C. Bodurka, C. Levenback, J. K. Wolf, J. Gano, J. T. Wharton, J. J. Kavanagh, and D. M. Gershenson
Phase II Trial of Irinotecan in Patients With Metastatic Epithelial Ovarian Cancer or Peritoneal Cancer
J. Clin. Oncol., January 15, 2003; 21(2): 291 - 297.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. M. Kirkwood, C. Bender, S. Agarwala, A. Tarhini, J. Shipe-Spotloe, B. Smelko, S. Donnelly, and L. Stover
Mechanisms and Management of Toxicities Associated With High-Dose Interferon Alfa-2b Therapy
J. Clin. Oncol., September 1, 2002; 20(17): 3703 - 3718.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
B. Holzner, G. Kemmler, R. Greil, M. Kopp, A. Zeimet, M. Raderer, M. Hejna, S. Zochbauer, G. Krajnik, H. Huber, et al.
The impact of hemoglobin levels on fatigue and quality of life in cancer patients
Ann. Onc., June 1, 2002; 13(6): 965 - 973.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
J. Glaspy, L. Degos, M. Dicato, and G. D. Demetri
Comparable Efficacy of Epoetin Alfa for Anemic Cancer Patients Receiving Platinum- and Nonplatinum-Based Chemotherapy: A Retrospective Subanalysis of Two Large, Community-Based Trials
Oncologist, April 1, 2002; 7(2): 126 - 135.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
X. S. Wang, S. A. Giralt, T. R. Mendoza, M. C. Engstrom, B. A. Johnson, N. Peterson, L. D. Broemeling, and C. S. Cleeland
Clinical Factors Associated With Cancer-Related Fatigue in Patients Being Treated for Leukemia and Non-Hodgkin's Lymphoma
J. Clin. Oncol., March 1, 2002; 20(5): 1319 - 1328.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
I. Quirt, C. Robeson, C. Y. Lau, M. Kovacs, S. Burdette-Radoux, S. Dolan, S. C. Tang, M. McKenzie, and F. Couture
Epoetin Alfa Therapy Increases Hemoglobin Levels and Improves Quality of Life in Patients With Cancer-Related Anemia Who Are Not Receiving Chemotherapy and Patients With Anemia Who Are Receiving Chemotherapy
J. Clin. Oncol., November 1, 2001; 19(21): 4126 - 4134.
[Abstract] [Full Text] [PDF]

Home page
 AM J HOSP PALLIAT CAREHome page
J. M. Cox and M. Pappagallo
Modafinil: A gift to portmanteau
American Journal of Hospice and Palliative Medicine, November 1, 2001; 18(6): 408 - 410.
[Abstract] [PDF]

Home page
 BMJHome page
G. A Curt
Fatigue in cancer
BMJ, June 30, 2001; 322(7302): 1560 - 1560.
[Full Text]

Home page
 JCOHome page
J. Savard and C. M. Morin
Insomnia in the Context of Cancer: A Review of a Neglected Problem
J. Clin. Oncol., February 1, 2001; 19(3): 895 - 908.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
R. K. Portenoy
Cancer-Related Fatigue: An Immense Problem
Oncologist, October 1, 2000; 5(5): 350 - 352.
[Full Text]

Home page
 The OncologistHome page
G. A. Curt, W. Breitbart, D. Cella, J. E. Groopman, S. J. Horning, L. M. Itri, D. H. Johnson, C. Miaskowski, S. L. Scherr, R. K. Portenoy, et al.
Impact of Cancer-Related Fatigue on the Lives of Patients: New Findings From the Fatigue Coalition
Oncologist, October 1, 2000; 5(5): 353 - 360.
[Abstract] [Full Text]

Home page
 The OncologistHome page
G. A. Curt
The Impact of Fatigue on Patients with Cancer: Overview of FATIGUE 1 and 2
Oncologist, June 1, 2000; 5(2008): 9 - 12.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow eLetters: Submit a response to this article
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints/Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Portenoy, R. K.
Right arrow Articles by Itri, L. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Portenoy, R. K.
Right arrow Articles by Itri, L. M.

HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
THE ONCOLOGIST STEM CELLS CME ALPHAMED PRESS JOURNALS