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Table 3. Clinical trials reported using CHOP as one of the treatment arms with prednisone dose at levels II-VI
n of Patients
 Histology (n)
 Ann Arbor Stage (n)
Study All/eligible CHOP All CHOP CHOP
L.G.1 I/H.G.2 L.G.1 I/H.G.2 I-II III-IV
Level II = Prednisone 100 mg/m2/day for 5 days
Gottlieb3 [20] 43/33   9 —  33 —   9 —   9
Gordon [43] 392/325 174 — 325 — 174 — 174
Glick [47] NA/345 345 — 345 — 345 345 —
Bezwoda4 [48] 150/150 150 — 150 — 150  81  69
Zinzani [49] 115/103  52 — 103 —  52   8  44
Gomez5 [50] 73/67  34 —  67 —  34 NA NA
Level III = Prednisone 75 mg/m2/day for 5 days
Meyer [51] 68/38  19 —  38 —  19   8  11
Connors [52] 78/78  78 —  78 —  78  78 —
Level IV = Prednisone 60 mg/m2/day for 5 days
Montserrat [53] 175/148  76 — 148 —  76  22  54
Yahalom6 [54] 44/44  18  16  26   6  12  18 —
Level V = Prednisone 50 mg/m2/day for 5 days
Linch7 [55] 471/459 226 — 459 — 226  79 147
Bezwoda8 [56] 359/263 132 — 263 — 132  27 105
Hagberg [57] 153/145  70 — 145 —  70 —  70
Sonneveld [58] 157/148  72 — 148 —  72  15  57
Tirelli [59] 130/120  60 — 120 —  60  23  37
Kaku8 [60] 62/62  62 NA NA NA NA  21  41
Elias [61] 31/23  23 —  23 —  23   2  21
Kimby [62] 259/259 127 259 — 127 — — 127
Pavlovsky [63] 97/89  44 —  89 —  44  10  34
Level VI = Prednisone 40 mg/m2/day for 5 days
Takagi9 [64] 57/57  29 —  57 —  29  11  18
Schaafsma [65] 102/102  21 — 102 —  21   4  17
1L.G. = Low grade and "favorable" histology.
2I/H.G = Intermediate/high-grade and "unfavorable" histology.
3CTX 600 mg/m2/i.v./day 1, ADR 40 mg/m2/i.v./day 1, VCR 1.4 mg/m2/i.v./day 1, prednisone 100 mg/m2/po/days 1-5.
4CTX 600 mg/m2/i.v./day 1, ADR 70 mg/m2/i.v./day 1, VCR 1.4 mg/m2/i.v./day 1, prednisolone 100 mg/m2/po/days 1-5.
5CTX 750 mg/m2/i.v./day 1, ADR 50 mg/m2/i.v./day 1, VCR 1 mg/m2/i.v./day 1 and day 8, prednisone 100 mg/m2/po/days 1-5.
6CTX 600 mg/m2/i.v./day 1, ADR 40 mg/m2/i.v./day 1, VCR 1.4 mg/m2/i.v./day 1, prednisone 60 mg/m2/po/days 1-5.
7CTX 750 mg/m2/i.v./day 1, ADR 25 mg/m2/i.v./day 1 and day 8, VCR mg/m2/i.v./day 1 and day 8, prednisolone 50 mg/m2/po/days 1-8.
8Prednisolone 50 mg/m2/i.v./days 1-5.
9TX 650 mg/m2/i.v./day 1, ADR 45 mg/m2/i.v./day 1, VCR 1.5 mg/m2/i.v./day 1, prednisone 40 mg/m2/po/days 1-5.





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